Built on decades of research
The scientific foundation for i-Lumen's bioelectric therapy spans more than 30 years of case studies, feasibility research, preclinical investigation, and controlled trials.
1991-1998
Early Clinical Observation
Initial clinical observations informed development of the loading-week treatment regimen and monophasic stimulation algorithm.
1998–2001
Feasibility Study
Early feasibility studies investigated visual function outcomes associated with bioelectric stimulation in retinal disease.
2002–2005
Preclinical Research Studies
Research at Schepens Eye Institute evaluated neuroprotective signaling, photoreceptor survival, and inflammatory pathway modulation.
2014–2024
Open Label Clinical Evaluation Study
Longitudinal clinical evaluation investigated visual acuity outcomes associated with the investigational therapy.
2020–2021
Computational Modeling Study
Modeling studies evaluated current distribution within ocular tissues and polarity effects across RPE cells.
2022–2024
i-SIGHT Study
A multicenter pilot study evaluated safety and visual function outcomes in intermediate to advanced dry AMD.
Advancing the i-SIGHT2 Pivotal Study
i-Lumen Scientific is advancing the clinical development of the investigational i-LUMEN™ AMD System through the ongoing i-SIGHT2 pivotal study.
The multicenter, randomized, controlled trial is enrolling sites across the United States, United Kingdom, Australia, and New Zealand to further evaluate safety, retinal function, and visual outcomes in patients with intermediate to advanced dry AMD.